West Nile virus
From Wikipedia, the free encyclopedia
West Nile Virus | |
---|---|
Virus classification | |
Group: | Group IV ((+)ssRNA) |
Family: | Flaviviridae |
Genus: | Flavivirus |
Species: | West Nile virus |
West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the family Flaviviridae. This flavivirus is found in temperate and tropical regions of the world. It was first identified in the West Nile subregion in the East African nation of Uganda in 1937. Prior to the mid 1990s, WNV disease occurred only sporadically and was considered a minor risk for humans, until an outbreak in Algeria in 1994, with cases of WNV-caused encephalitis, and the first large outbreak in Romania in 1996, with a high number of cases with neuroinvasive disease. WNV has now spread globally, with the first case in the Western Hemisphere being identified in New York City in 1999;[1] over the next 5 years, the virus spread across the continental United States, north into Canada, and southward into the Caribbean Islands and Latin America. WNV also spread to Europe, beyond the Mediterranean Basin [a new strain of the virus was recently (2012) identified in Italy]. WNV is now considered to be an endemic pathogen in Africa, Asia, Australia, the Middle East, Europe and in the United States, which in 2012 has experienced one of its worst epidemics.
The main mode of WNV transmission is via various species of mosquitoes which are the prime vector, with birds being the most commonly infected animal and serving as the prime reservoir host - especially passerines which are of the largest order (Passeriformes) of birds. WNV has been found in various species of ticks, but current research suggests they are not important vectors of the virus. WNV also infects various mammal species, including humans, and has been identified in reptilian species, including alligators and crocodiles, and also in amphibians. Not all animal species which are susceptible to WNV infection – humans included, and not all bird species develop sufficient viral levels to transmit the disease to uninfected mosquitoes, and are thus not considered major factors in WNV transmission.[2][3]
Approximately 80% of West Nile virus infections in humans are subclinical, which cause no symptoms.[4] In the cases where symptoms do occur – termed West Nile fever in cases without neurological disease – the time from infection to the appearance of symptoms (incubation period) is typically between 2 and 15 days. Symptoms may include fever, headaches, fatigue, muscle pain or aches, malaise, nausea, anorexia, vomiting, myalgias and rash. Less than 1% of the cases are severe and result in neurological disease when the central nervous system is affected. People of advanced age, the very young, or those with immunosuppression, either medically induced, such as those taking immunosupressive drugs, or due to a pre-existing medical condition such as HIV infection, are most susceptible. The specific neurological diseases which may occur are West Nile encephalitis, which causes inflammation of the brain, West Nile meningitis, which causes inflammation of the meninges which are the protective membranes that cover the brain and spinal cord, West Nile meningoencephalitis, which causes inflammation of the brain and also the meninges surrounding it, and West Nile poliomyelitis - spinal cord inflammation which results in a syndrome similar to polio, which may cause acute flaccid paralysis.
Currently, no vaccine against WNV infection is available. The best method to reduce the rates of WNV infection is mosquito control on the part of municipalities, businesses and individual citizens to reduce breeding populations of mosquitoes in public, commercial and private areas via various means including eliminating standing pools of water where mosquitoes breed, such as in old tires, buckets, disused swimming pools, etc. On an individual basis, the use of personal protective measures to avoid being bitten by an infected mosquito, via the use of mosquito repellent, window screens, avoiding areas where mosquitoes are more prone to congregate, such as near marshes, areas with heavy vegetation etc., and being more vigilant from dusk to dawn when mosquitoes are most active offers the best defense. In the event of being bitten by an infected mosquito, familiarity of the symptoms of WNV on the part of laypersons, physicians and allied health professionals affords the best chance of receiving timely medical treatment which may aid in reducing associated possible complications and also appropriate palliative care.
2012 West Nile virus update: October 2
As of October 2, 2012, 48 states have reported West Nile virus infections in people, birds, or mosquitoes. A total of 3,969 cases of West Nile virus disease in people, including 163 deaths, have been reported to CDC. Of these, 2,010 (51%) were classified as neuroinvasive disease (such as meningitis or encephalitis) and 1,959 (49%) were classified as non-neuroinvasive disease.
The 3,969 cases reported thus far in 2012 is the highest number of West Nile virus disease cases reported to CDC through the first week in October since 2003. Almost 70 percent of the cases have been reported from eight states (Texas, California, Louisiana, Mississippi, South Dakota, Michigan, Oklahoma, and Illinois) and a third of all cases have been reported from Texas.
West Nile Virus (WNV) Human Infections Reported to ArboNET, by
State, United States, 2012 (as of October 2, 2012)
Human Disease Cases Reported To CDC | |||||
---|---|---|---|---|---|
State | Neuroinvasive Disease Cases | Non–Neuroinvasive Disease Cases | Total Cases* | Deaths | Presumptive Viremic Blood Donors† |
Totals | 2,010 | 1,959 | 3,969 | 163 | 508 |
Alabama | 24 | 7 | 31 | 1 | 0 |
Arizona | 40 | 27 | 67 | 1 | 23 |
Arkansas | 37 | 14 | 51 | 6 | 4 |
California | 121 | 95 | 216 | 10 | 41 |
Colorado | 50 | 56 | 106 | 3 | 0 |
Connecticut | 8 | 8 | 16 | 0 | 1 |
Delaware | 1 | 5 | 6 | 1 | 0 |
District Of Columbia | 2 | 0 | 2 | 1 | 0 |
Florida | 35 | 13 | 48 | 2 | 4 |
Georgia | 27 | 18 | 45 | 4 | 11 |
Idaho | 3 | 8 | 11 | 0 | 2 |
Illinois | 108 | 45 | 153 | 5 | 16 |
Indiana | 12 | 50 | 62 | 6 | 14 |
Iowa | 6 | 13 | 19 | 0 | 6 |
Kansas | 15 | 17 | 32 | 1 | 0 |
Kentucky | 4 | 2 | 6 | 0 | 3 |
Louisiana | 107 | 106 | 213 | 11 | 31 |
Maryland | 18 | 17 | 35 | 3 | 12 |
Massachusetts | 15 | 5 | 20 | 1 | 0 |
Michigan | 127 | 51 | 178 | 10 | 36 |
Minnesota | 32 | 34 | 66 | 1 | 31 |
Mississippi | 88 | 114 | 202 | 5 | 20 |
Missouri | 10 | 4 | 14 | 1 | 8 |
Montana | 0 | 5 | 5 | 0 | 0 |
Nebraska | 17 | 68 | 85 | 1 | 22 |
Nevada | 5 | 1 | 6 | 1 | 1 |
New Hampshire | 1 | 0 | 1 | 0 | 0 |
New Jersey | 16 | 19 | 35 | 2 | 4 |
New Mexico | 19 | 17 | 36 | 1 | 6 |
New York | 45 | 28 | 73 | 4 | 12 |
North Carolina | 6 | 0 | 6 | 2 | 2 |
North Dakota | 32 | 45 | 77 | 0 | 17 |
Ohio | 60 | 37 | 97 | 4 | 14 |
Oklahoma | 90 | 72 | 162 | 9 | 35 |
Oregon | 0 | 3 | 3 | 0 | 0 |
Pennsylvania | 15 | 7 | 22 | 1 | 4 |
Rhode Island | 2 | 2 | 4 | 0 | 0 |
South Carolina | 16 | 8 | 24 | 3 | 11 |
South Dakota | 58 | 137 | 195 | 3 | 42 |
Tennessee | 16 | 10 | 26 | 0 | 1 |
Texas | 674 | 764 | 1438 | 54 | 58 |
Utah | 1 | 2 | 3 | 0 | 0 |
Vermont | 1 | 0 | 1 | 0 | 0 |
Virginia | 11 | 8 | 19 | 2 | 2 |
Washington | 3 | 1 | 4 | 0 | 0 |
West Virginia | 3 | 0 | 3 | 0 | 0 |
Wisconsin | 26 | 12 | 38 | 3 | 13 |
Wyoming | 3 | 4 | 7 | 0 | 1 |
* Includes confirmed and probable cases.
†Of the 508 presumptive viremic blood donors, 76 (15%) developed clinical illness and are also included as "Human disease cases reported to CDC".
†Of the 508 presumptive viremic blood donors, 76 (15%) developed clinical illness and are also included as "Human disease cases reported to CDC".
West Nile virus (WNV) activity reported to ArboNET, by state, United States, 2012 (as of October 2, 2012)
Footnote: The map displays white areas that represent no WNV activity reported, light green areas that represent any WNV activity* , dark green circles that represent disease cases, and dark green triangles that represent presumptive viremic blood donors.
* Includes WNV human disease cases, presumptive viremic blood donors, veterinary disease cases and infections in mosquitoes, birds, and sentinel animals.
† Presumptive viremic blood donors have a positive screening test which has not necessarily been confirmed.
† Presumptive viremic blood donors have a positive screening test which has not necessarily been confirmed.
Map shows the distribution of WNV activity* (shaded in light green), human infections (dark green circles), and presumptive viremic blood donors (dark green triangles) occurring during 2012 by state. If West Nile virus infection is reported from any area of a state, that entire state is shaded.
Data table:
Non-human West Nile virus infections have been reported to CDC ArboNET from the following states:
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin and Wyoming.
Four thousand four hundred and one human West Nile virus infections have been reported to CDC ArboNET from Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming.
For information on WNV activity in Canada please see:http://www.phac-aspc.gc.ca/wnv-vwn/index.html
| ||
No comments:
Post a Comment