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Showing posts with label drug resistant organism. Show all posts
Showing posts with label drug resistant organism. Show all posts

Saturday, April 9, 2011

Warning: Bacteria With Superbug Gene

Scientists issue urgent world-wide warning on bacteria with superbug gene

Friday, April 08, 2011 by: S. L. Baker, features writer
scientists calling for the "urgent need for global action". This time, it's worrisome news about a gene that turns bacteria into not just superbugs -- but SUPER superbugs.

Bottom line:this gene (dubbed the New Delhi metallo-s-lactamase 1 gene, NDM-1, for short) enables bacteria to resist virtually any and perhaps all antibiotics.

These multidrug-resistantbacteriahave been found in publicwatersupplies and urban effluent in New Delhi. But this isn't a problem limited toIndia. While researchers writing in the latest issue of the journalLancetsay the findings in India pose the worrisome possibility that NDM-1 is widespread in the environment of that country, there are plenty of reasons to be concerned the bacteria could be spreading to other parts of the planet.

Mohd Shahid from Jawaharlal Nehru Medical College and Hospital in Uttar Pradesh, India, warns in an accompanying article that the potential for the global spread of bacteria with the super dangerous NDM-1 gene ".. is real and should not be ignored...coordinated, concrete, and collective efforts are needed, initially to limit their widespread dissemination, and finally to combat this emerging threatening resistance problem."

For the new study, Timothy Walsh from Cardiff University in the UK and hisresearchteam, in collaboration with reporters from Channel 4 television, investigated how common NDM-1-producing bacteria are in community waste seepage (water pools in streets or rivulets) and public tap water in urban New Delhi. Using a variety of sophisticated tests, including DNA probing, the researchers checked for the presence of the NDM-1 gene in bacteria found in the water samples.

The results? The NDM-1 gene was found in 2 of the 50 drinking-water samples and 51 of 171 seepage samples. NDM-1 positive bacteria were grown from 2 drinking-water samples and 12 seepage samples. And there was a surprise -- the gene was found in 20 bacterial isolates comprising 14 different species,including 11 species in which NDM-1 has not been previously reported.What's more, the researchers reported in a media statement that it is particularly worrisome that the superbug-causing gene has spread to extremely pathogenic species of bacteria, including Shigella boydii and Vibrio cholerae, which cause dysentery and cholera, respectively.

That means bacteria that can already make people extremely sick and even kill are now turning up with a gene that makes those disease-causing germs even more dangerous because it makes them "bullet proof" from antibiotics.

The new superbug-with-a-super-gene problem is centered in India at the moment. The situation is largely blamed on a lack of sanitation -- 650 million people or more in India don't have access to clean water, according to the researchers' media statement. Moreover, it turns out that the rate at which the NDM-1 gene is copied and transferred between different bacteria is highest at 30°C and that falls within the daily range of temperatures in New Delhi for 7 months of the year from April to October.


Learn more:http://www.naturalnews.com/032004_superbug_bacteria.html#ixzz1J3RerWux

Friday, April 8, 2011

SUPERBUG. SUPER RESISTANT. SUPER KILLER.

SUPERBUG THAT IS A SUPER KILLER


Carbapenem-Resistant Klebsiella pneumoniae, or CRKP
Map of CRE Superbug which kills 40% of people who come in contact


CDC INFORMATION



Public Health update of Carbapenem-Resistant Enterobacteriaceae (CRE) producing metallo-beta-lactamases (NDM, VIM, IMP) in the U.S. reported to CDC

Given the importance of Enterobacteriaceae in healthcare-associated infections (HAI) and the extensive antimicrobial resistance found in these strains, all types of carbapenem-resistant Enterobacteriaceae (CRE) are an important public health problem, regardless of their mechanism of resistance or their country of origin. In addition, as Enterobacteriaceae are a normal part of human flora, the potential for community-associated CRE infections also exists. Carbapenem-resistance in Enterobacteriaceae can occur by many mechanisms, including the production of a metallo-beta-lactamase (such as NDM, VIM, and IMP) or a carbapenemase (such as Klebsiella pneumoniae carbapenemase, KPC).
CDC has been working with partners to prevent CRE infections, including those caused by KPC-producing organisms, which are the most common type of CRE in the United States. The KPC gene makes Enterobacteriaceae bacteria resistant to all beta-lactam/carbapenem antibiotics. KPC producers have been reported in about 35 states and are associated with high mortality, up to 40 percent in one report. They may be present in the other 15 states as well, but have not been reported to CDC.  The presence of CRE, regardless of the enzyme that produced that resistance, reinforces the need for better antibiotic stewardship, transmission prevention, and overall HAI prevention in any healthcare setting.
The detection of new mechanisms of carbapenem resistance (ie, metallo-beta-lactamases) in the United States has raised questions about the identification and control of CRE. The mechanism of carbapenem-resistance is of epidemiologic interest but is not necessary for implementation of infection prevention recommendations. Current guidance for the control of all types of epidemiologically important multidrug-resistant organisms is available in the2006 MDRO Guideline. In addition, see specific guidance for the control of CRE. These recommendations apply regardless of the resistance mechanism.
It is important to note that CRE, unlike other drug-resistant infections such as VRSA, are not a nationally reportable or notifiable disease. Therefore, there is not a requirement to report to CDC and therefore we may not know the true number of infections caused by these organisms in the US (only those voluntarily reported to CDC).

States with confirmed CRE cases caused by the KPC enzyme.

Alabama
Arizona
Arkansas
California (CRE caused by the NDM-1 enzyme and VIM or IMP enzyme)
Colorado
Delaware
Florida
Georgia
Illinois (CRE caused by the NDM-1 enzyme)
Indiana
Iowa
Kentucky
Louisiana
Maryland
Massachusetts (CRE caused by the NDM-1 enzyme)
Michigan
Minnesota
Mississippi
Missouri
Nebraska
Nevada
New Hampshire
New Jersey
New Mexico
New York
North Carolina
Ohio
Oregon
Pennsylvania
South Carolina
Tennessee
Texas
Utah
Virginia (CRE caused by the NDM-1 enzyme)
West Virginia
Wisconsin
Wyoming

State(s) with confirmed CRE cases caused by a VIM or IMP enzyme

Washington